Sperm DNA Fragmentation Assays Correlate with Sperm Abnormal Morphology and the Pregnancy Outcome

It has been documented that almost 50% of the infertility problems are at present attributed to male factors. In IVF centres, potential infertile men are screened for the sperm quality by semen analysis, in particular investigating concentration, motility and morphology according to WHO guidelines [1]. However, at present, these parameters appear to be poor predictors of the fertilization success since infertile men may often show normal semen analysis [2]. For these reasons, it is claimed that, due to poor diagnostic methods and no fully effective infertility treatments, the use of sperm functionality test should be mandatory and routinely associated to conventional semen analysis [3-5].